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Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity by Milan Urban; Jan Sarek; Iva Tislerova; Petr Dzubak; Marian Hajduch is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The aim of this work was to find an optimal ester group for preparation of lupane derivatives connecting high cytotoxicity with good chemical and pharmacological properties. Activities of methyl-, pivaloyloxymethyl- (Pom-), and acetoxymethyl- (Acm-) esters were compared with the activity of free acids. Although the methyl- and Pom-esters were generally less active than free acids, some Acm-esters had cytotoxicity similar to or even better than the starting compounds. Cytotoxic activity was measured in five cancer cell lines.

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Author

Milan Urban; Jan Sarek; Iva Tislerova; Petr Dzubak; Marian Hajduch

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)