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Anticancer potential of gold nanoparticles (AuNPs) using a battery of in vitro tests by Nouf Omar Alafaleq; Alya Alomari; Mohd Shahnawaz Khan; Gouse M. Shaik; Afzal Hussain; Faheem Ahmed; Iftekhar Hassan; Ibrahim M. Alhazza; Majed S. Alokail; Amal Majed H. Alenad; Nasimudeen R. Jabir; Shams Tabrez is a Engineering article available to read on EtoBox.
What is Anticancer potential of gold nanoparticles (AuNPs) using a battery of in vitro tests about?
This study synthesized gold nanoparticles (AuNPs) using a facile microwave-assisted chemical route and evaluated them as potential anticancer candidates against breast and colon cancer cell lines. Numerous spectral characterization tools were used to study the optical properties, structure, and morphology of the prepared AuNPs. UV-Vis spectroscopy showed a characteristic peak at 517 nm, which confirms the formation of AuNPs. The crystalline structure of NPs was studied by X-ray diffraction, and the NPs' shape and size were calculated with Field emission transmission electron microscopy. The synthesized AuNPs were found to be uniform in size in the range of 2-6 nm. A variety of biological tests, including MTT, scratch, real time polymerase chain reaction (RT-PCR), and comet assays were adopted to assess the anticancer potential of these AuNPs in the studied cancer cell models. The findings suggested a cell-dependent cytotoxicity of AuNPs. Different cell viability of 40.3 and 66.4% were obtained for MCF-7 and HCT-116, respectively, at 5 μg/mL of AuNPs. The scratch assay showed AuNPs impede cell migration in a concentration-dependent manner in the MCF-7 cell line. On the other hand, r
Who reads Anticancer potential of gold nanoparticles (AuNPs) using a battery of in vitro tests?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Nouf Omar Alafaleq; Alya Alomari; Mohd Shahnawaz Khan; Gouse M. Shaik; Afzal Hussain; Faheem Ahmed; Iftekhar Hassan; Ibrahim M. Alhazza; Majed S. Alokail; Amal Majed H. Alenad; Nasimudeen R. Jabir; Shams Tabrez
- Publisher
- Walter de Gruyter GmbH
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)