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Comparison of Propofol Versus Propofol–ketamine Combination in Pediatric Oncologic Procedures Performed by Non-anesthesiologists by Antonio Chiaretti; Antonio Ruggiero; Egidio Barbi; Filomena Pierri; Palma Maurizi; Claudia Fantacci; Giulia Bersani; Riccardo Riccardi is a Medicine article available to read on EtoBox.

What is Comparison of Propofol Versus Propofol–ketamine Combination in Pediatric Oncologic Procedures Performed by Non-anesthesiologists about?

## Abstract ## Background Limited data are available on the best option (short acting sedatives, opioids, or ketamine) in oncologic procedural sedation performed by non‐anesthesiologists. The aim of the present prospective study is to compare the safety and efficacy of propofol–ketamine versus propofol alone, managed by trained pediatricians, in children with cancer undergoing painful procedures. ## Procedures Data on 121 children with acute lymphatic leukemia (ALL) undergoing procedural sedations (lumbar punctures and bone marrow aspirations) were prospectively collected and included drug doses, side effects, pain assessment, and sedation degree. Children were randomly assigned to one of the two groups: P (n = 62) receiving propofol alone and K (n = 59) in whom a ketamine–propofol combination was used. ## Results In group K, the total dose of propofol required was significantly lower than in group P (3.9 ± 3.6 mg/kg vs. 5.1 ± 3.6 mg/kg; __P__ < 0.001). The incidence of hypotension was also significantly lower (11% vs. 39%; __P__ < 0.001). Major O~2~ desaturations (defined as SatO~2~ < 88%) occurred principally in group P (7 vs. 1; __P__ = 0.05). Both best analgesia and shorter rec

Who reads Comparison of Propofol Versus Propofol–ketamine Combination in Pediatric Oncologic Procedures Performed by Non-anesthesiologists?

Author

Antonio Chiaretti; Antonio Ruggiero; Egidio Barbi; Filomena Pierri; Palma Maurizi; Claudia Fantacci; Giulia Bersani; Riccardo Riccardi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2011

Language

EN

Field

Medicine (Health Sciences)