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Can I read Osteopontin Is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis on EtoBox?
Osteopontin Is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis by Wing-Kin Syn; Steve S. Choi; Evaggelia Liaskou; Gamze F. Karaca; Kolade M. Agboola; Ye Htun Oo; Zhiyong Mi; Thiago A. Pereira; Marzena Zdanowicz; Padmini Malladi; Yuping Chen; Cynthia Moylan; Youngmi Jung; Syamal D. Bhattacharya; Vanessa Teaberry; Alessia Omenetti; Manal F. Abdelmalek; Cynthia D. Guy; David H. Adams; Paul C. Kuo; Gregory A. Michelotti; Peter F. Whitington; Anna Mae Diehl is a Medicine article available to read on EtoBox.
What is Osteopontin Is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis about?
Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed that NASH-related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix protein and cytokine, is a direct transcriptional target of the Hh pathway. Thus, we hypothesize that Hh signaling induces OPN to promote liver fibrosis in NASH. Hepatic OPN expression and liver fibrosis were analyzed in wild-type (WT) mice, Patched-deficient (Ptc 1/2 ) (overly active Hh signaling) mice, and OPNdeficient mice before and after feeding methionine and choline-deficient (MCD) diets to induce NASH-related fibrosis. Hepatic OPN was also quantified in human NASH and nondiseased livers. Hh signaling was manipulated in cultured liver cells to assess direct effects on OPN expression, and hepatic stellate cells (HSCs) were cultured in medium with different OPN activities to determine effects on HSC phenotype. When fed MCD diets, Ptc 1/2 mice expressed more OPN and developed worse liver fibrosis (P < 0.05) than WT mice, whereas OPN-deficient mice exhibited reduced fibrosis (P < 0.05). In NASH patients, OPN was significantly up-regulated
Who reads Osteopontin Is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wing-Kin Syn; Steve S. Choi; Evaggelia Liaskou; Gamze F. Karaca; Kolade M. Agboola; Ye Htun Oo; Zhiyong Mi; Thiago A. Pereira; Marzena Zdanowicz; Padmini Malladi; Yuping Chen; Cynthia Moylan; Youngmi Jung; Syamal D. Bhattacharya; Vanessa Teaberry; Alessia Omenetti; Manal F. Abdelmalek; Cynthia D. Guy; David H. Adams; Paul C. Kuo; Gregory A. Michelotti; Peter F. Whitington; Anna Mae Diehl
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)