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A Placebo-Controlled Study Evaluating the Efficacy and Safety of Flexible-Dose Desvenlafaxine Treatment in Outpatients with Major Depressive Disorder by Alan D. Feiger; Karen A. Tourian; Gregory R. Rosas; S. Krishna Padmanabhan is a Medicine article available to read on EtoBox.

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## Introduction: This research compares the efficacy and safety of desvenlafaxine (administered as desvenlafaxine succinate) versus placebo in treating major depressive disorder. ## Methods: In this randomized, double-blind study, outpatients with major depressive disorder > or =18 years of age received desvenlafaxine 200-400 mg/day or placebo for 8 weeks. efficacy endpoints included (primary) change in 17-item hamilton rating scale for depression score at the final evaluation (last observation carried forward, analysis of covariance) and (secondary) clinical global impressions-improvement and -severity of illness scales. ## Results: The difference between desvenlafaxine (n==) and placebo (n==) on the primary endpoint was not significant (-9.1 vs -7.5, p=.078). week 8 observed cases (desvenlafaxine, n=80; placebo, n=94) results were significant (-10.7 vs -7.9, p=.008). differences at the final evaluation (last observation carried forward) were significant for clinical global impressions-improvement (2.9 vs 2.5, p=.037) and clinical global impressions-severity of illness (-1.9 vs -1.2, p=.041). discontinuation rates due to adverse events (aes) were 12% and 3% for desvenlafaxine and

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Author

Alan D. Feiger; Karen A. Tourian; Gregory R. Rosas; S. Krishna Padmanabhan

Publisher

Cambridge University Press (CUP)

Published

2009

Language

EN

Field

Medicine (Health Sciences)