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Clinical features of bacterial meningitis among hospitalised children in Kenya by Obiero, Christina W. (author);Mturi, Neema (author);Mwarumba, Salim (author);Ngari, Moses (author);Newton, Charles R. (author);van Hensbroek, Michaël Boele (author);Berkley, James A. (author) is a Medicine article available to read on EtoBox.
What is Clinical features of bacterial meningitis among hospitalised children in Kenya about?
## Background Diagnosing bacterial meningitis is essential to optimise the type and duration of antimicrobial therapy to limit mortality and sequelae. In sub-Saharan Africa, many public hospitals lack laboratory capacity, relying on clinical features to empirically treat or not treat meningitis. We investigated whether clinical features of bacterial meningitis identified prior to the introduction of conjugate vaccines still discriminate meningitis in children aged ≥60 days. ## Methods We conducted a retrospective cohort study to validate seven clinical features identified in 2002 (__KCH-2002__): bulging fontanel, neck stiffness, cyanosis, seizures outside the febrile convulsion age range, focal seizures, impaired consciousness, or fever without malaria parasitaemia and Integrated Management of Childhood Illness (IMCI) signs: neck stiffness, lethargy, impaired consciousness or seizures, and assessed at admission in discriminating bacterial meningitis after the introduction of conjugate vaccines. Children aged ≥60 days hospitalised between 2012 and 2016 at Kilifi County Hospital were included in this analysis. Meningitis was defined as positive cerebrospinal fluid (CSF) culture, orga
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- Author
- Obiero, Christina W. (author);Mturi, Neema (author);Mwarumba, Salim (author);Ngari, Moses (author);Newton, Charles R. (author);van Hensbroek, Michaël Boele (author);Berkley, James A. (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)