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Nonviable Staphylococcus aureus and its peptidoglycan stimulate macrophage recruitment, angiogenesis, fibroplasia, and collagen accumulation in wounded rats by Jack K. Kilcullen; Quan P. Ly; Tsueng H. Chang; Stanley M. Levenson; Jacob J. Steinberg is a Medicine article available to read on EtoBox.

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We have previously shown that local application at the time of operation of Staphylococcus aureus, nonviable S, aureus, its cell wall, or S. aureus peptidoglycan accelerates wound healing . We hypothesized that this effect is due to both direct and indirect mechanisms, among which is an increase in the inflammatory response to wounding, resulting in an increase in macrophages, angiogenesis, and fibroblasts . Twenty-seven Sprague-Dawley male rats were anesthetized, and two 7-cm paravertebral skin incisions were made . Four polyvinyl alcohol sponges, two on each side, containing either 100 pl of isotonic saline or 0.5 mg of nonviable S. aureus or S. aureus peptidoglycan in 100-pl saline were implanted subcutaneously . Nonviable S. aureus or S, aureus peptidoglycan (860 pg/cm incision) in 200-pl saline were inoculated into the incisions at closure. The rats ate a commercial rat chow and drank tap water ad libitum throughout . After days 3 and 7 postwounding, rats were euthanized, and tissues were examined for immunohistochemical features of reparative tissue using ED-1, Factor VIII, and vimentin antibodies, markers for monocyte/macrophages, endothelial cells, and mesenchymal cells (in

Who reads Nonviable Staphylococcus aureus and its peptidoglycan stimulate macrophage recruitment, angiogenesis, fibroplasia, and collagen accumulation in wounded rats?

Author

Jack K. Kilcullen; Quan P. Ly; Tsueng H. Chang; Stanley M. Levenson; Jacob J. Steinberg

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)

Published

1998

Language

EN

Field

Medicine (Health Sciences)