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Solid-state and Particle Size Control of Pharmaceutical Cocrystals Using Atomization-based Techniques by Aaron O'Sullivan; Barry Long; Vivek Verma; Kevin M. Ryan; Luis Padrela is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Solid-state and Particle Size Control of Pharmaceutical Cocrystals Using Atomization-based Techniques about?

Poor bioavailability and aqueous solubility represent a major constraint during the development of new API molecules and can influence the impact of new medicines or halt their approval to the market. Cocrystals offer a novel and competitive advantage over other conventional methods with respect towards the substantial improvement in solubility profiles relative to the single-API crystals. Furthermore, the production of such cocrystals through atomization-based methods allow for greater control, with respect to particle size reduction, to further increase the solubility of the API. Such atomization-based methods include supercritical fluid methods, conventional spray drying and electrohydrodynamic atomization/electrospraying. The influence of process parameters such as solution flow rates, pressure and solution concentration, in controlling the solid-state and final particle size are discussed in this review with respect to atomization-based methods. For the last decade, literature has been attempting to catch-up with new regulatory rulings regarding the classification of cocrystals, due in part to data sparsity. In recent years, there has been an increase in cocrystal publications

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Author

Aaron O'Sullivan; Barry Long; Vivek Verma; Kevin M. Ryan; Luis Padrela

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)