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Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells by Feiqi Zhu; Fujun Wu; Ying Ma; Guangjian Liu; Zhong Li; Yong’an Sun; Zhong Pei is a Neuroscience article available to read on EtoBox.

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## Background Berberine (BER), the major alkaloidal component of __Rhizoma coptidis__, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and neurotrophic effects. It has also been demonstrated that BER can reduce the production of beta-amyloid~40/42~, which plays a critical and primary role in the pathogenesis of Alzheimer's disease. However, the mechanism by which it accomplishes this remains unclear. ## Results Here, we report that BER could not only significantly decrease the production of beta-amyloid~40/42~ and the expression of beta-secretase (BACE), but was also able to activate the extracellular signal-regulated kinase1/2 (ERK1/2) pathway in a dose- and time-dependent manner in HEK293 cells stably transfected with APP695 containing the Swedish mutation. We also find that U0126, an antagonist of the ERK1/2 pathway, could abolish (1) the activation activity of BER on the ERK1/2 pathway and (2) the inhibition activity of BER on the production of beta-amyloid~40/42~ and the expression of BACE. ## Conclusion Our data indicate that BER decreases the production of beta-

Who reads Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells?

Author

Feiqi Zhu; Fujun Wu; Ying Ma; Guangjian Liu; Zhong Li; Yong’an Sun; Zhong Pei

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2202)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)