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Intensive Insulin Therapy in Critically Ill Patients by Greet Van den Berghe; Pieter Wouters; Frank Weekers; Charles Verwaest; Frans Bruyninckx; Miet Schetz; Dirk Vlasselaers; Patrick Ferdinande; Peter Lauwers; Roger Bouillon is a Medicine article available to read on EtoBox.

What is Intensive Insulin Therapy in Critically Ill Patients about?

Background Hyperglycemia and insulin resistance are common in critically ill patients, even if they have not previously had diabetes. Whether the normalization of blood glucose levels with insulin therapy improves the prognosis for such patients is not known. ## Methods We performed a prospective, randomized, controlled study involving adults admitted to our surgical intensive care unit who were receiving mechanical ventilation. On admission, patients were randomly assigned to receive intensive insulin therapy (maintenance of blood glucose at a level between 80 and 110 mg per deciliter) or conventional treatment (infusion of insulin only if the blood glucose level exceeded 215 mg per deciliter and maintenance of glucose at a level between 180 and 200 mg per deciliter). ## Results At 12 months, with a total of 1548 patients enrolled, intensive insulin therapy reduced mortality during intensive care from 8.0 percent with conventional treatment to 4.6 percent (P<0.04, with adjustment for sequential analyses). The benefit of intensive insulin therapy was attributable to its effect on mortality among patients who remained in the intensive care unit for more than five days (20.2 percent

Who reads Intensive Insulin Therapy in Critically Ill Patients?

Author

Greet Van den Berghe; Pieter Wouters; Frank Weekers; Charles Verwaest; Frans Bruyninckx; Miet Schetz; Dirk Vlasselaers; Patrick Ferdinande; Peter Lauwers; Roger Bouillon

Publisher

Massachusetts Medical Society

Published

2001

Language

EN

Field

Medicine (Health Sciences)