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Acute Cholinergic Rescue of Synaptic Plasticity in the Neurodegenerating Cortex of Anti‐nerve‐growth‐factor Mice by Emanuele Pesavento; Simona Capsoni; Luciano Domenici; Antonino Cattaneo is a Neuroscience article available to read on EtoBox.

What is Acute Cholinergic Rescue of Synaptic Plasticity in the Neurodegenerating Cortex of Anti‐nerve‐growth‐factor Mice about?

## Abstract Deficits in cholinergic systems innervating cerebral cortex are associated with cognitive impairment during senescence and in age‐related neurodegenerative pathologies. However, little is known about the role of cholinergic pathways in modulating cortical plasticity. Basal forebrain cholinergic neurons are a major target for nerve‐growth factor (NGF). In order to investigate the relationship between cholinergic innervation and cortical synaptic plasticity, we exploited a transgenic mouse model in which the activity of NGF in the adult nervous system is neutralized by the expression of blocking antibodies to NGF itself (anti‐NGF mice) [Ruberti, F. __et al__. (2000). __J. Neurosci__. 20, 2589–2601]. In 6‐month‐old anti‐NGF mice, we show that the reduction in cholinergic innervation of the cortex is associated with different forms of synaptic plasticity impairment. A local, acute increase in the availability of acetylcholine rescues these synaptic plasticity deficits, thus indicating that a cholinergic system mediates the impairment of cortical plasticity at this early stage of the neurodegenerative process triggered by NGF neutralization. Our results represent an importan

Who reads Acute Cholinergic Rescue of Synaptic Plasticity in the Neurodegenerating Cortex of Anti‐nerve‐growth‐factor Mice?

Author

Emanuele Pesavento; Simona Capsoni; Luciano Domenici; Antonino Cattaneo

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)