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Transforming growth factor-β1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like cytokine profile by Åsa Schiött; Bengt Widegren; Hans Olov Sjögren; Magnus Lindvall is a Immunology and Microbiology article available to read on EtoBox.

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TGF-b is a known regulator of hematopoietic cells. In this study we suggest a major role of adherent spleen cells (adh-splc), to convert an inhibitory effect of TGF-b1 on T-cell activation into a stimulatory effect. We show that interaction of TGF-b1 with adh-splc induces a costimulatory effect on T-cell proliferation. This costimulatory signal requires the adh-splc to be in physical contact with the T-cells. Presence of adh-splc results in a shift towards a Th2-like response with a cytokine profile of increased IL-10 and decreased IFN-g. In the adh-splc population the increase of IL-10 is most pronounced at start of activation, whereas in the T-lymphocyte population, IL-10 increases at the end of culture. The suppression of the IFN-g production by TGF-b1 is shown to be an important mechanism by which TGF-b enhances proliferation of Th2 lymphocytes.

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Author

Åsa Schiött; Bengt Widegren; Hans Olov Sjögren; Magnus Lindvall

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)