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Differential and Shared Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Serum Metabolome in Subjects with Chronic Inflammation by Chang, Wan-Chi (author);So, Jisun (author);Lamon-Fava, Stefania (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Differential and Shared Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Serum Metabolome in Subjects with Chronic Inflammation about?

The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) affect cell function and metabolism, but the differential effects of EPA and DHA are not known. In a randomized, controlled, double-blind, crossover study, we assessed the effects of 10-week supplementation with EPA-only and DHA-only (3 g/d), relative to a 4-week lead-in phase of high oleic acid sunflower oil (3 g/day, defined as baseline), on fasting serum metabolites in 21 subjects (9 men and 12 post-menopausal women) with chronic inflammation and some characteristics of metabolic syndrome. Relative to baseline, EPA significantly lowered the tricarboxylic acid (TCA) cycle intermediates fumarate and α-ketoglutarate and increased glucuronate, UDP-glucuronate, and non-esterified DHA. DHA significantly lowered the TCA cycle intermediates pyruvate, citrate, isocitrate, fumarate, α-ketoglutarate, and malate, and increased succinate and glucuronate. Pathway analysis showed that both EPA and DHA significantly affected the TCA cycle, the interconversion of pentose and glucuronate, and alanine, and aspartate and glutamate pathways (FDR < 0.05) and that DHA had a significantly greater effect on the TCA cycle

Who reads Differential and Shared Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Serum Metabolome in Subjects with Chronic Inflammation?

Author

Chang, Wan-Chi (author);So, Jisun (author);Lamon-Fava, Stefania (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)