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Atypical teratoid/rhabdoid tumor of the central nervous system: Clinico-pathological study by Min-Cheol Lee; Seung-Kyu Park; Joon-Sup Lim; Shin Jung; Jae-Hyoo Kim; Young-Jong Woo; Ji-Shin Lee; Hyung-Ihl Kim; Myung-Ja Jeong; Ha-Young Choi is a Medicine article available to read on EtoBox.
What is Atypical teratoid/rhabdoid tumor of the central nervous system: Clinico-pathological study about?
Atypical teratoid/rhabdoid tumor (AT/RT) is a new entity among malignant pediatric brain tumors. This study was performed to investigate the clinicopathologic and cytogenetic features of the tumor. Five cases from a series of the brain tumors were studied. Clinical features of the patients were assessed with age, sex, location of the tumors, treatments and survival periods. Histopathologic features were analyzed by routine HE stain and immunohistochemical stains for epithelial membrane antigen, cytokeratin, vimentin, smooth muscle actin, desmin, GFAP, S-100 protein, neurofilament protein, synaptophysin and alpha-feto protein. Cytogenetic studies for karyotype analysis and fluorescent in situ hybridization were available in three cases. Mean age of patients was 5.6 years, and maximal survival periods were less than 13 months despite surgical and radiation therapy. The tumors were located in infratentorial and supratentorial areas. Histopathologically, the tumors were chiefly composed of rhabdoid cells, modified rhabdoid cells and undifferentiated small cells, mixed with epithelial, mesenchymal, and neural tumor-like areas. These polyphenotypic features of the tumor cells were suppor
Who reads Atypical teratoid/rhabdoid tumor of the central nervous system: Clinico-pathological study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Min-Cheol Lee; Seung-Kyu Park; Joon-Sup Lim; Shin Jung; Jae-Hyoo Kim; Young-Jong Woo; Ji-Shin Lee; Hyung-Ihl Kim; Myung-Ja Jeong; Ha-Young Choi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0919-6544)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)