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Homocyst(e)ine and Risk of Cardiovascular Disease in the Multiple Risk Factor Intervention Trial by Evans, Rhobert W.; Shaten, B. Jessica; Hempel, John D.; Cutler, Jeffrey A.; Kuller, Lewis H. is a Medicine article available to read on EtoBox.

__Abstract__ A nested case-control study was undertaken involving men participating in the Multiple Risk Factor Intervention Trial (MRFIT). Serum samples from 712 men, stored for up to 20 years, were analyzed for homocyst(e)ine. Cases involved nonfatal myocardial infarctions (MIs), identified through the active phase of the study, which ended on February 28, 1982, and deaths due to coronary heart disease (CHD), monitored through 1990. The nonfatal MIs occurred within 7 years of sample collection, whereas the majority of CHD deaths occurred more than 11 years after sample collection. Mean homocyst(e)ine concentrations were in the expected range and did not differ significantly between case patients and control subjects: MI cases, 12.6 μmol/L; MI controls, 13.1 μmol/L; CHD death cases, 12.8 μmol/L; and CHD controls, 12.7 μmol/L. Odds ratios versus quartile 1 for CHD deaths and MIs combined were as follows: quartile 2, 1.03; quartile 3, 0.84; and quartile 4, 0.92. Thus, in this prospective study, no association of homocyst(e)ine concentration with heart disease was detected. Homocyst(e)ine levels were weakly associated with the acute-phase protein (C-reactive protein). These results a

Author

Evans, Rhobert W.; Shaten, B. Jessica; Hempel, John D.; Cutler, Jeffrey A.; Kuller, Lewis H.

Publisher

Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)

Published

1997

Language

EN

Field

Medicine (Health Sciences)