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Low Glycemic Index Treatment in Patients with Drug-resistant Epilepsy by Se Hee Kim; Hoon-Chul Kang; Eun Joo Lee; Joon Soo Lee; Heung Dong Kim is a Medicine article available to read on EtoBox.

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## Objective: Low glycemic index treatment (lgit) is a newly developed dietary therapeutic option for epilepsy that is less restrictive than the ketogenic diet (kd). our objective was to determine the efficacy and tolerability of lgit. ## Methods: From march 2014 to february 2015, 36 patients received lgit at severance children's hospital. one-year seizure outcomes and side effects were evaluated. ## Results: A total of 36 patients were assessed. fourteen were female. common diagnoses were lennox-gastaut syndrome (33%, 12/36) and dravet syndrome (14%, 5/36). the median age at the initiation of the lgit was 12.6years (min.=1.5, max.=28, interquartile range (iqr) 8-17). after 3months of therapy, 20 (56%) patients experienced a 50% or greater reduction in seizure frequency, which was maintained in 19 (53%) patients for 1year. two (6%) patients became seizure-free after 3months of lgit; they remained seizure-free for 1year. these two had dravet syndrome and generalized epilepsy. only three (8%) patients discontinued treatment within 1year. adverse events were rare, and two patients (6%) reported transient diarrhea. ## Conclusions: Lgit effectively reduced seizure frequency in the prese

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Author

Se Hee Kim; Hoon-Chul Kang; Eun Joo Lee; Joon Soo Lee; Heung Dong Kim

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)