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Can I read Heterocyclic Amines: Evaluation of Their Role in Diet Associated Human Cancer on EtoBox?
Heterocyclic Amines: Evaluation of Their Role in Diet Associated Human Cancer by N. J. GOODERHAM; S. MURRAY; A. M. LYNCH; R. J. EDWARDS; M. YADOLLAHI‐FARSANI; C. BRATT; K. J. RICH; K. ZHAO; B. P. MURRAY; S. BHADRESA; S. J. CROSBIE; A. R. BOOBIS; D. S. DAVIES is a Medicine article available to read on EtoBox.
What is Heterocyclic Amines: Evaluation of Their Role in Diet Associated Human Cancer about?
1Heterocyclic amines are formed in parts per billion levels when meat is cooked. 2The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the systemic circulation after ingestion of cooked food. 3We have shown that MeIQx and PhIP, both __in vitro__ and __in vivo__, are substrates for human hepatic CYP1A2, which exclusively and efficiently catalyses their conversion to genotoxic hydroxylamines. 4MeIQx and PhIP are promutagens. MeIQx is a very powerful bacterial mutagen whereas PhIP is a more potent mammalian cell mutagen. Using a mammalian cell target gene, __hprt__, we have shown that PhIP induces a characteristic mutational ‘fingerprint’. 5MeIQx and PhIP are carcinogenic in bioassays. The PhIP mutational ‘fingerprint’ has been detected in the __Apc__ gene of 5/8 colonic tumours induced by PhIP in rats.
Who reads Heterocyclic Amines: Evaluation of Their Role in Diet Associated Human Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- N. J. GOODERHAM; S. MURRAY; A. M. LYNCH; R. J. EDWARDS; M. YADOLLAHI‐FARSANI; C. BRATT; K. J. RICH; K. ZHAO; B. P. MURRAY; S. BHADRESA; S. J. CROSBIE; A. R. BOOBIS; D. S. DAVIES
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)