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Can I read Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis on EtoBox?
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis by Kwangho Kim; Tae Young Ryu; Eunsun Jung; Tae-Su Han; Jinkwon Lee; Seon-Kyu Kim; Yu Na Roh; Moo-Seung Lee; Cho-Rok Jung; Jung Hwa Lim; Ryuji Hamamoto; Hye Won Lee; Keun Hur; Mi-Young Son; Dae-Soo Kim; Hyun-Soo Cho is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis about?
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone methyltransferase SMYD2 is overexpressed in lung cancer and that knockdown of SMYD2 could reduce the rates of cell migration and invasion in lung cancer cell lines via direct downregulation of SMAD3 via SMYD2-mediated epigenetic regulation. Furthermore, using an in vitro epithelial-mesenchymal transition (EMT) system with a Transwell system, we generated highly invasive H1299 (In-H1299) cell lines and observed the suppression of metastatic features by SMYD2 knockdown. Finally, two types of in vivo studies revealed that the formation of metastatic tumors by shSMYD2 was significantly suppressed. Thus, we suggest that SMYD2 is a potential metastasis regulator and that the development of SMYD2-specific inhibitors may help to increase the efficacy of lung cancer treatment.
Who reads Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kwangho Kim; Tae Young Ryu; Eunsun Jung; Tae-Su Han; Jinkwon Lee; Seon-Kyu Kim; Yu Na Roh; Moo-Seung Lee; Cho-Rok Jung; Jung Hwa Lim; Ryuji Hamamoto; Hye Won Lee; Keun Hur; Mi-Young Son; Dae-Soo Kim; Hyun-Soo Cho
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)