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CD45: A Critical Regulator of Signaling Thresholds in Immune Cells by Michelle L. Hermiston; Zheng Xu; Arthur Weiss is a Immunology and Microbiology article available to read on EtoBox.

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▪ Abstract Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of protein tyrosine kinases and phosphatases. CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates signals emanating from integrin and cytokine receptors. Recent work has focused on regulation of CD45 expression and alternative splicing, isoform-specific differences in signal transduction, and regulation of phosphatase activity. From these studies, a model is emerging in which CD45 affects cellular responses by controlling the relative threshold of sensitivity to external stimuli. Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 functi

Who reads CD45: A Critical Regulator of Signaling Thresholds in Immune Cells?

Author

Michelle L. Hermiston; Zheng Xu; Arthur Weiss

Publisher

Annual Reviews

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)