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Can I read Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance on EtoBox?
Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance by Silvia Graziano; Maria Rosaria Varì; Simona Pichini; Francesco Paolo Busardo; Tommaso Cassano; Annagiulia Di Trana is a Neuroscience article available to read on EtoBox.
What is Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance about?
## Background During the last two years, hexahydrocannabinol (HHC), the hydrogenated derivative of tetrahydrocannabinol has been freely sold by internet websites as a “legal” replacement to THC and cannabis in a range of highly attractive branded and unbranded products, some of which are sold as “legal highs”. Potentially, there could be a large demand for HHC products by individuals in Europe and internationally. ## Methods Studies reporting HHC pharmacology, toxicology and analysis were identified from Pubmed and Scopus databases, and official international organizations’ websites were considered. ## Results HHC showed the effects of the typical cannabinoid on the central nervous system, with lower potency than Δ^9^-THC. A few studies highlighted that **9(R)**-HHC is more potent than **9(S)**-HHC. This molecule showed an affinity for cannabinoid receptor CB1 both __in vitro__ and __in vivo__, suggesting a possible therapeutic effect in several pathologies. However, the affinity for the CB1 receptor suggests a possible addiction potential, inducing the users to misuse it. Since actual intoxication cases have not yet been reported, the HHC harmful potential was not described, proba
Who reads Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Silvia Graziano; Maria Rosaria Varì; Simona Pichini; Francesco Paolo Busardo; Tommaso Cassano; Annagiulia Di Trana
- Publisher
- Bentham Science Publishers
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)