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Antiplasmodial activity of sesquilignans and sesquineolignans from Bonamia spectabilis by Carola Kraft; Kristina Jenett-Siems; Inga Köhler; Britta Tofern-Reblin; Karsten Siems; Ulrich Bienzle; Eckart Eich is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Phytochemical re-investigation of the aerial parts of Bonamia spectabilis (Convolvulaceae) led to the isolation of four minor tetrahydrofuran-type sesquilignans (bonaspectins E-H) together with the known neolignan virolongin A and the known lignan rel-(7S,8R,7 0 R,8 0 R)-3,3 0 ,4,4 0 ,5,5 0 -hexamethoxylignan. Their structures were established on the basis of spectral data. These six compounds as well as further seven lignanoids from B. spectabilis, characterised previously, were tested for their antiplasmodial activity against a chloroquine-sensitive strain (PoW) and a chloroquine-resistant clone (Dd2) of Plasmodium falciparum. Bonaspectin C 4 00 -O-glucoside, its aglycone, and bonaspectin D 4 00 -O-glucoside revealed the highest antiplasmodial activities (IC 50 values: 1.3, 2.0, 6.5 mM [ PoW ]; 1.7, 4.6, 3.7 mM [ Dd2], respectively).

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Author

Carola Kraft; Kristina Jenett-Siems; Inga Köhler; Britta Tofern-Reblin; Karsten Siems; Ulrich Bienzle; Eckart Eich

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)