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Localized in Vivo Proton Spectroscopy of the Bone Marrow in Patients with Leukemia by Karl Erik Jensen; Mikael Jensen; Peter Grundtvig; Carsten Thomsen; Hans Karle; Ole Henriksen is a Medicine article available to read on EtoBox.

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Volume selective magnetic resonance (MR) proton spectroscopy was used to investigate the haemopoietic (iliac bone) and fatty bone marrow (tibia) in patients with leukemia and polycythaemia Vera. Selective measurements of the relaxation times Ti and T2 for the "water" and "fat" resonances in the bone marrow spectra were performed. Nine patients with acute leukemia and three patients with chronic leukemia were examined at diagnosis. Three patients with acute leukemia in remission were also examined. Five of the leukemic patients had follow-up examinations performed in relation to chemotherapeutic treatment. Nine patients with polycythaemia vera and 21 normal control subjects were examined with identical methods for comparison. Ah patients had bone marrow biopsies performed prior to every MR examination. Significant differences could be detected in the spectral patterns from iliac bone marrow in patients with leukemia at diagnosis compared to the healthy normal controls. The "relative water content" was increased in the iliac bone marrow spectra of the leukemic patients compared to the normal subjects, which indicates an increase in the amount of haemopoietic tissue and a correspondin

Who reads Localized in Vivo Proton Spectroscopy of the Bone Marrow in Patients with Leukemia?

Author

Karl Erik Jensen; Mikael Jensen; Peter Grundtvig; Carsten Thomsen; Hans Karle; Ole Henriksen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)

Published

1990

Language

EN

Field

Medicine (Health Sciences)