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Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry by K. Riecke; V. Müller; T. Neunhöffer; T.-W. Park-Simon; R. Weide; A. Polasik; M. Schmidt; J. Puppe; C. Mundhenke; K. Lübbe; T. Hesse; M. Thill; R. Wuerstlein; C. Denkert; T. Decker; T. Fehm; V. Nekljudova; J. Rey; S. Loibl; E. Laakmann; I. Witzel is a Medicine article available to read on EtoBox.

What is Long-term survival of breast cancer patients with brain metastases: subanalysis of the BMBC registry about?

## Background Up to 30% of metastatic breast cancer (BC) patients develop brain metastases (BM). Prognosis of patients with BM is poor and long-term survival is rare. Identification of factors associated with long-term survival is important for improving treatment modalities. ## Patients and methods A total of 2889 patients of the national registry for BM in BC (BMBC) were available for this analysis. Long-term survival was defined as overall survival (OS) in the upper third of the failure curve resulting in a cut-off of 15 months. A total of 887 patients were categorized as long-term survivors. ## Results Long-term survivors compared to other patients were younger at BC and BM diagnosis (median 48 versus 54 years and 53 versus 59 years), more often had HER2-positive tumors (59.1% versus 36.3%), less frequently luminal-like (29.1% versus 35.7%) or triple-negative breast cancer (TNBC) (11.9% versus 28.1%), showed better Eastern Cooperative Oncology Group (ECOG) performance status (PS) at the time of BM diagnosis (ECOG 0-1, 76.9% versus 51.0%), higher pathological complete remission rates after neoadjuvant chemotherapy (21.6% versus 13.7%) and lower number of BM (__n__ = 1, BM 40.9%

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Author

K. Riecke; V. Müller; T. Neunhöffer; T.-W. Park-Simon; R. Weide; A. Polasik; M. Schmidt; J. Puppe; C. Mundhenke; K. Lübbe; T. Hesse; M. Thill; R. Wuerstlein; C. Denkert; T. Decker; T. Fehm; V. Nekljudova; J. Rey; S. Loibl; E. Laakmann; I. Witzel

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)