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Pathogenesis of Vascular Dementia in Stroke-prone Spontaneously Hypertensive Rats by Shinichi Kimura; Hideya Saito; Masaru Minami; Hiroko Togashi; Nishio Nakamura; Masahiro Nemoto; Hasan S. Parvez is a Environmental Science article available to read on EtoBox.

What is Pathogenesis of Vascular Dementia in Stroke-prone Spontaneously Hypertensive Rats about?

Stroke-prone spontaneously hypertensive rats (SHRSP) are the best model for essential hypertension and stroke. In this study, one investigated whether SHRSP might be a useful animal model for vascular dementia. An impairment of learning-memory function was found in SHRSP. A disturbance in circadian rhythm after stroke in SHRSP was clarified. Desynchronization of light and dark alternation cycles and abnormal rhythm were also demonstrated. These observations point to the possibility that the decreased passive avoidance response observed in SHRSP might be similar to the phenomenon of memory impairment in patients with vascular dementia. The behavioral changes in ambulation in SHRSP, including the desynchronization between light and dark alternation cycles and the abnormal rhythm before death, might correspond to the behavioral changes associated with the delirium-state observed in patients with dementia. Cerebral cortex levels of acetylcholine and choline in SHRSP decreased significantly as compared with the Wistar Kyoto rats (WKY) control group. Hippocampal levels of acetylcholine and choline in SHRSP decreased significantly as compared with those in WKY. Moreover, a correlation bet

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Author

Shinichi Kimura; Hideya Saito; Masaru Minami; Hiroko Togashi; Nishio Nakamura; Masahiro Nemoto; Hasan S. Parvez

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2000

Language

EN

Field

Environmental Science (Life Sciences)