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Can I read Declining malformation rates with changed antiepileptic drug prescribing: An observational study on EtoBox?
Declining malformation rates with changed antiepileptic drug prescribing: An observational study by Torbjörn Tomson; Dina Battino; Erminio Bonizzoni; John Craig; Dick Lindhout; Emilio Perucca; Anne Sabers; Sanjeev V. Thomas; Frank Vajda; for The EURAP Study Group is a Medicine article available to read on EtoBox.
What is Declining malformation rates with changed antiepileptic drug prescribing: An observational study about?
## Objective Changes in prescribing patterns of antiepileptic drugs (AEDs) in pregnant women with epilepsy would be expected to affect the risk of major congenital malformations (MCMs). To test this hypothesis, we analyzed data from an international pregnancy registry (EURAP). ## Methods EURAP is an observational prospective cohort study designed to determine the risk of MCMs after prenatal exposure to AEDs. The Cochrane-Armitage linear trend analysis was used to assess changes in AED treatment, prevalence of MCMs, and occurrence of generalized tonic-clonic seizures (GTCs) over 3 time periods: 2000–2005 (n = 4,760), 2006–2009 (n = 3,599), and 2010–2013 (n = 2,949). ## Results There were pronounced changes in the use of specific AEDs over time, with a decrease in the use of valproic acid and carbamazepine and an increase in the use of lamotrigine and levetiracetam. The prevalence of MCMs with monotherapy exposure decreased from 6.0% in 2000–2005 to 4.4% in 2010–2013. The change over time in MCM frequency after monotherapy exposure showed a significant linear trend in the crude analysis (__p__ = 0.0087), which was no longer present after adjustment for changes in AED treatment (__p__
Who reads Declining malformation rates with changed antiepileptic drug prescribing: An observational study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Torbjörn Tomson; Dina Battino; Erminio Bonizzoni; John Craig; Dick Lindhout; Emilio Perucca; Anne Sabers; Sanjeev V. Thomas; Frank Vajda; for The EURAP Study Group
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)