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Cripto, a Member of the Epidermal Growth Factor Family, Is Over-expressed in Human Pancreatic Cancer and Chronic Pancreatitis by Helmut Friess; Yoichiro Yamanaka; Markus Büchler; Michael S. Kobrin; Eiichi Tahara; Murray Korc is a Medicine article available to read on EtoBox.

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## Abstract Cripto is a 188 amino‐acid protein containing a central segment that shares amino‐acid sequence homology with epidermal growth factor (EGF) and transforming growth factor alpha (TGF‐α). The EGF receptor, EGF and TGF‐α are expressed in the normal human pancreas, and are over‐expressed in human pancreatic cancer. Therefore, in the present study we sought to determine whether cripto is found in the normal human pancreas and whether its expression is altered in pancreatic cancer. Because chronic pancreatitis (CP) is associated with interstitial fibrosis similar to that observed in pancreatic cancer, we also examined cripto expression in pancreatic tissues from patients with CP. In the normal pancreas, cripto immunoreactivity was found at moderate levels in most ductal cells and was present very faintly in a rare acinar cell. In 26 of 58 pancreatic cancers, cripto immunoreactivity was present in many cancer cells. Its presence was associated with advanced tumor stage, but not with shorter post‐operative survival. Cripto was also present in acinar and ductal cells adjacent to the cancer cells, and in many ductal and atrophic acinar cells in the CP samples. Northern blot analy

Who reads Cripto, a Member of the Epidermal Growth Factor Family, Is Over-expressed in Human Pancreatic Cancer and Chronic Pancreatitis?

Author

Helmut Friess; Yoichiro Yamanaka; Markus Büchler; Michael S. Kobrin; Eiichi Tahara; Murray Korc

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1994

Language

EN

ISBN

9782910560515

Field

Medicine (Health Sciences)