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1135: Development of a Three-Dimensional Anisotropic Pelvic Lymph Node Clinical Target Volume and Planning Target Volume Using Magnetic Resonance Lymphadenography With Ferumoxtran-10 by R. Dinniwell; P. Chan; M. Haider; A. Fyles; M. Milosevic is a Medicine article available to read on EtoBox.

What is 1135: Development of a Three-Dimensional Anisotropic Pelvic Lymph Node Clinical Target Volume and Planning Target Volume Using Magnetic Resonance Lymphadenography With Ferumoxtran-10 about?

Purpose/Objective(s): Embryonic lymphatic development occurs in close parallel to the vascular system. Improved knowledge of the spatial relationship between the two will enhance the utility of the vasculature as a surrogate for radiotherapy treatment planning. To develop three-dimensional anisotropic scale factors for the use of the pelvic vasculature as a surrogate for lymph node target definition using Magnetic Resonance Imaging (MRI) with an ultra-small superparamagnetic iron oxide that delineates phagocytotic activity within lymph nodes. Materials/Methods: A single center trial was undertaken in patients with genitourinary and gynecological malignancies. All patients underwent pre-and post-contrast MRI studies over two consecutive days with intravenous hyoscine butylbromide given as an inhibitor of bowel peristalsis. Ferumoxtran-10 (Combidex®: Advanced Magnetics, Inc, Cambridge, MA) was administered on the first day. Axial images were obtained at 3 mm intervals through the pelvis. Lymph node frequency and location relative to the adjacent vascular segments was analyzed. Each lymph node was divided into 0.5 x 0.5 x 3 mm 3 nodal voxels. The radial position and minimal distance b

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Author

R. Dinniwell; P. Chan; M. Haider; A. Fyles; M. Milosevic

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2006

Language

EN

Field

Medicine (Health Sciences)