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Progressive Expansion of Hypertensive Intracerebral Hemorrhage by Coagulopathy by Takahashi, Hiroshi; Urano, Tetsumei; Nagai, Nobuo; Takada, Yumiko; Takada, Akikazu is a Medicine article available to read on EtoBox.

What is Progressive Expansion of Hypertensive Intracerebral Hemorrhage by Coagulopathy about?

To test the hypothesis that an impaired coagulation system facilitates rapid expansion of hypertensive intracerebral hemorrhage (HICH), coagulation markers were assayed in plasma and their relations to both the hemorrhage size and its progressive expansion were analyzed. Ninety patients with HICH were studied. On admission, plasma samples were taken for the coagulation assay. Hematoma volume was calculated from a computed tomography (CT) scan and its enlargement was estimated by comparison to the volume of the hematoma calculated from a second CT scan taken later within 24 hr. Nine out of 90 patients showed enlargement in their hematoma size (enlarged hematoma group). Four of the enlarged hematoma group fell into acute fatal deterioration and died. Plasma levels of both fibrino peptide A (17.2 ± 7.8 vs. 4.0 ± 0.6 ng/ml, P < 0.05) and thrombinantithrombin complex (21.9 ± 3.1 vs. 7.4 ± 2.8 ng/ml, not significant) were higher in the unchanged group than those in the enlarged hematoma group. In the hematoma-enlarged group fibrino-peptide A level did not exceed 10 ng/ml. In the hematoma unchanged group thrombin-AT-III complex values were positively correlated to hematoma volume. Thus, t

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Author

Takahashi, Hiroshi; Urano, Tetsumei; Nagai, Nobuo; Takada, Yumiko; Takada, Akikazu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

1998

Language

EN

Field

Medicine (Health Sciences)