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Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes by Hariklia Kranidioti; Stylianos E. Orfanos; Ilia Vaki; Anastasia Kotanidou; Maria Raftogiannis; Ioanna Dimopoulou; Antigoni Kotsaki; Athina Savva; Andreas Papapetropoulos; Apostolos Armaganidis; Evangelos J. Giamarellos-Bourboulis is a Immunology and Microbiology article available to read on EtoBox.
What is Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes about?
We aimed to investigate if angiopoietin-2 (Ang-2) participates in the septic process and what may be the role of monocytes as a site of release of Ang-2 in sepsis. Concentrations of Ang-2 were estimated in sera and in supernatants of monocytes derived form one already described cohort of 90 patients with septic syndrome due to ventilator-associated pneumonia (VAP). Mononuclear cells of 17 healthy volunteers were stimulated by serum of patients in the presence or absence of various intracellular pathway inhibitors. Ang-2 gene expression after stimulation was also tested. Ang-2 was higher in patients with septic shock compared to patients with sepsis, severe sepsis and controls. Ang-2 was significantly increased in nonsurvivors compared with survivors. Serum levels greater than 9700 pg/ml were accompanied by a 3.254 odds ratio for death (p: 0.033). Ang-2 release from monocytes of septic patients was slightly decreased after stimulation with lipopolysaccharide (LPS) of Escherichia coli O55:B5. Release of Ang-2 from healthy mononuclear cells was stimulated by serum of patients with shock but not by serum of non-shocked patients (p: 0.016). Release was decreased by LPS; increased in the
Who reads Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Hariklia Kranidioti; Stylianos E. Orfanos; Ilia Vaki; Anastasia Kotanidou; Maria Raftogiannis; Ioanna Dimopoulou; Antigoni Kotsaki; Athina Savva; Andreas Papapetropoulos; Apostolos Armaganidis; Evangelos J. Giamarellos-Bourboulis
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)
- Published
- 2009
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)