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Accuracy of SelectMDx compared to mpMRI in the diagnosis of prostate cancer: a systematic review and diagnostic meta-analysis by Reza Sari Motlagh; Takafumi Yanagisawa; Tatsushi Kawada; Ekaterina Laukhtina; Pawel Rajwa; Abdulmajeed Aydh; Frederik König; Maximilan Pallauf; Nicolai A. Huebner; Pascal A. Baltzer; Pierre I. Karakiewicz; Axel Heidenreich; Shahrokh F. Shariat is a Medicine article available to read on EtoBox.
What is Accuracy of SelectMDx compared to mpMRI in the diagnosis of prostate cancer: a systematic review and diagnostic meta-analysis about?
## Background: The selectmdx test is a promising biomarker that is developed based on detecting urinary messenger rna in combination with clinical prostate cancer (pca) risk factors. we aimed to compare selectmdx and mpmri as a diagnostic test in detecting pca and high grade(hg)-pca in men suspected to have pca. ## Methods: According to prisma, a systematic search was performed using major web databases for studies published before september 30, 2021. studies that compared sensitivity, specificity, positive predictive value (ppv), and negative predictive value (npv) of selectmdx and/or mpmri were included. the bivariate random model that plotted sensitivity, specificity, ppv, npv, and likelihood ratio (lr) for pca and hg-pca detection was applied to compare selectmdx, mpmri, and combination strategies (both positive and one or both positive). ## Results: Seven studies comprising 1328 patients who had undergone selectmdx and mpmri to detect pca were included. regarding pca detection, selectmdx had a pooled sensitivity of 81%, specificity of 69.8%, ppv of 64.7%, npv of 85%, and lrs of +2.68 to -0.27, while mpmri had a pooled sensitivity of 80.8%, specificity of 73.4%, ppv of 72.4%, n
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- Author
- Reza Sari Motlagh; Takafumi Yanagisawa; Tatsushi Kawada; Ekaterina Laukhtina; Pawel Rajwa; Abdulmajeed Aydh; Frederik König; Maximilan Pallauf; Nicolai A. Huebner; Pascal A. Baltzer; Pierre I. Karakiewicz; Axel Heidenreich; Shahrokh F. Shariat
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)