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Can I read Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K on EtoBox?
Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K by Robert W Marquis; Yu Ru; Dennis S Yamashita; Hye-Ja Oh; Jack Yen; Scott K Thompson; Thomas J Carr; Mark A Levy; Thaddeus A Tomaszek; Carl F Ijames; Ward W Smith; Baoguang Zhao; Cheryl A Janson; Sherin S Abdel-Meguid; Karla J D'Alessio; M.S McQueney; Daniel F Veber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K about?
AbstractÐCathepsin K (EC 3.4.22.38) is a cysteine protease of the papain superfamily which is selectively expressed within the osteoclast. Several lines of evidence have pointed to the fact that this protease may play an important role in the degradation of the bone matrix. Potent and selective inhibitors of cathepsin K could be important therapeutic agents for the control of excessive bone resorption. Recently a series of peptide aldehydes have been shown to be potent inhibitors of cathepsin K. In an eort to design more selective and metabolically stable inhibitors of cathepsin K, a series of electronically attenuated alkoxymethylketones and thiomethylketones inhibitors have been synthesized. The X-ray co-crystal structure of one of these analogues in complex with cathepsin K shows the inhibitor binding in the primed side of the enzyme active site with a covalent interaction between the active site cysteine 25 and the carbonyl carbon of the inhibitor.
Who reads Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Robert W Marquis; Yu Ru; Dennis S Yamashita; Hye-Ja Oh; Jack Yen; Scott K Thompson; Thomas J Carr; Mark A Levy; Thaddeus A Tomaszek; Carl F Ijames; Ward W Smith; Baoguang Zhao; Cheryl A Janson; Sherin S Abdel-Meguid; Karla J D'Alessio; M.S McQueney; Daniel F Veber
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)