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Dietary Arachidonic Acid-mediated Effects on Colon Inflammation Using Transcriptome Analysis by Bianca Knoch; Matthew P. G. Barnett; Warren C. McNabb; Shuotun Zhu; Zaneta A. Park; Anar Khan; Nicole C. Roy is a Medicine article available to read on EtoBox.
What is Dietary Arachidonic Acid-mediated Effects on Colon Inflammation Using Transcriptome Analysis about?
## Abstract Increased levels of n‐6 arachidonic acid (AA), a precursor of pro‐inflammatory eicosanoids, have been found in the colon mucosa of inflammatory bowel disease patients when compared with healthy subjects. The hypothesis was that dietary AA would aggravate colon inflammation by changing expression of genes in inflammatory signaling pathways. AA‐enriched diet was fed to IL10 gene‐deficient (__Il10^−^^/^^−^__) mice, model of a inflammatory bowel disease, and compared with __Il10^−^^/^^−^__ mice fed an oleic acid control diet. Effects of AA on gene expression profiles during colitis were examined using whole genome microarray analysis. Dietary AA decreased the expression levels of some colonic genes in ER stress, complement system, nuclear respiratory factor 2‐mediated oxidative stress and positive acute phase response pathways compared with __Il10^−^^/^^−^__ mice fed an oleic acid diet. AA increased the expression levels of fatty acid catabolism genes, but decreased that of lipid synthesis genes during colitis, likely by sterol regulatory element binding transcription factor 1 and target gene regulation. A link has been suggested between AA and reduction of intestinal fibro
Who reads Dietary Arachidonic Acid-mediated Effects on Colon Inflammation Using Transcriptome Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bianca Knoch; Matthew P. G. Barnett; Warren C. McNabb; Shuotun Zhu; Zaneta A. Park; Anar Khan; Nicole C. Roy
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)