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Early use of plasmapheresis for recurrent post-transplant FSGS by Madhura Pradhan; Julie Petro; Joanne Palmer; Kevin Meyers; H. Jorge Baluarte is a Medicine article available to read on EtoBox.

What is Early use of plasmapheresis for recurrent post-transplant FSGS about?

Recurrence of focal segmental glomerulosclerosis (FSGS) in an allograft is a challenging clinical situation because it frequently results in graft loss. We report our experience with early use of plasmapheresis in recurrent FSGS. Of the 18 (33%) children with biopsy-proven FSGS (in their native kidneys) transplanted at our institution, 6 had recurrence (elevated urine protein/creatinine ratios) post transplant and were treated with plasmapheresis. Patients who received treatment within 1 day of the recurrence (4/6) went into remission after 5-13 plasmapheresis treatments, within 5-27 days of starting treatment. Patients who did not respond to plasmapheresis (2/6) were treated 7 and 17 days after onset of proteinuria; 1 of these had acute tubular necrosis and acute rejection leading to graft loss and the other developed acute rejections, ongoing proteinuria, and subsequent graft loss. All 4 patients who went into remission have maintained good graft function, 22-53 months post transplant. In our experience early institution of plasmapheresis for recurrent post-transplant proteinuria in FSGS is effective.

Who reads Early use of plasmapheresis for recurrent post-transplant FSGS?

Author

Madhura Pradhan; Julie Petro; Joanne Palmer; Kevin Meyers; H. Jorge Baluarte

Publisher

Springer Science and Business Media LLC

Published

2003

Language

EN

Field

Medicine (Health Sciences)