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Blunted Coronary Flow Velocity Reserve Is Associated with Impairment in Systolic Function and Functional Capacity in Hypertrophic Cardiomyopathy by Sílvia Aguiar Rosa; Luís Rocha Lopes; Luísa Branco; Ana Galrinho; António Fiarresga; Boban Thomas; Pedro Brás; António Gonçalves; Isabel Cardoso; Ana Papoila; Marta Alves; Pedro Rio; Inês Cruz; Mafalda Selas; Filipa Silva; Ana Silva; Rui Cruz Ferreira; Miguel Mota Carmo is a Medicine article available to read on EtoBox.

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## Background: Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (hcm). we aimed to assess the association between impaired coronary flow velocity reserve (cfvr) and ventricular systolic function and functional capacity. ## Methods: Eighty-three patients with hcm were enrolled in this prospective cohort study. patients underwent echocardiogram to evaluate ventricular performance and cfvr in the left anterior descending artery (lad) and posterior descending artery (pd). diastolic coronary flow velocity was measured in basal conditions and in hyperemia. cfvr was calculated as the ratio of hyperemic and basal peak diastolic flow velocities. functional capacity was evaluated by cardiopulmonary exercise testing (cpet). the link between cfvr and biventricular systolic function and peak vo was studied. ## Results: Age was 55.0(14.4)years, 50 patients (60%) were male; 59 patients (71%) had nonobstructive hcm. mean cfvr lad was 1.81(0.49) and cfvr pd was 1.73(0.55). lower cfvr pd was associated with impaired global longitudinal strain (gls) 2d (β-estimate:-3.240,95%ci:-4.634;-1.846, p < 0.001), gls 3d (β-estimate:-2.559,95%

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Author

Sílvia Aguiar Rosa; Luís Rocha Lopes; Luísa Branco; Ana Galrinho; António Fiarresga; Boban Thomas; Pedro Brás; António Gonçalves; Isabel Cardoso; Ana Papoila; Marta Alves; Pedro Rio; Inês Cruz; Mafalda Selas; Filipa Silva; Ana Silva; Rui Cruz Ferreira; Miguel Mota Carmo

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)