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Stereotactic Body Radiation Therapy for Lung Metastases from Soft Tissue Sarcoma by Pierina Navarria; Anna Maria Ascolese; Luca Cozzi; Stefano Tomatis; Giuseppe Roberto D’Agostino; Fiorenza De Rose; Rita De Sanctis; Andrea Marrari; Armando Santoro; Antonella Fogliata; Umberto Cariboni; Marco Alloisio; Vittorio Quagliuolo; Marta Scorsetti is a Medicine article available to read on EtoBox.

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## Purpose: To appraise the role of stereotactic body radiation therapy (sbrt) in patients with lung metastasis from primary soft tissue sarcoma. ## Methods: Twenty-eight patients (51 lesions) were analysed. all patients were in good performance status (1-2 eastern cooperative oncology group (ecog)), unsuitable for surgical resection, with controlled primary tumour and the number of lung metastases was ⩽4. in a risk adaptive scheme, the dose prescription was: 30gy/1fr, 60gy/3fr, 60gy/8fr and 48gy/4fr. treatments were performed with volumetric modulated arc therapy. clinical outcome was evaluated by thoracic and abdominal computed tomography (ct) scan before sbrt and than every 3months. toxicity was evaluated with common terminology criteria for adverse events (ctcae) scale version 4.0. ## Results: Leiomyosarcoma (36%) and synovial sarcoma (25%) were the most common histologies. five patients (18%) initially presented with pulmonary metastasis, whereas 23 (82%) developed them at a median time of 51months (range 11-311months) from the initial diagnosis. the median follow-up time from initial diagnosis was 65months (5-139months) and from sbrt was 21months (2-80months). no severe toxic

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Author

Pierina Navarria; Anna Maria Ascolese; Luca Cozzi; Stefano Tomatis; Giuseppe Roberto D’Agostino; Fiorenza De Rose; Rita De Sanctis; Andrea Marrari; Armando Santoro; Antonella Fogliata; Umberto Cariboni; Marco Alloisio; Vittorio Quagliuolo; Marta Scorsetti

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0959-8049)

Published

2015

Language

EN

Field

Medicine (Health Sciences)