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Biopsy‐Proven Small‐Fiber Neuropathy in Primary Sjögren's Syndrome: Neuropathic Pain Characteristics, Autoantibody Findings, and Histopathologic Features by Julius Birnbaum; Aliya Lalji; Aveen Saed; Alan N. Baer is a Medicine article available to read on EtoBox.

What is Biopsy‐Proven Small‐Fiber Neuropathy in Primary Sjögren's Syndrome: Neuropathic Pain Characteristics, Autoantibody Findings, and Histopathologic Features about?

## Objective Painful small‐fiber neuropathies (SFNs) in primary Sjögren's syndrome (SS) may present as pure or mixed with concurrent large‐fiber involvement. SFN can be diagnosed by punch skin biopsy results that identify decreased intra‐epidermal nerve‐fiber density (IENFD) of unmyelinated nerves. ## Methods We compared 23 consecutively evaluated patients with SS with pure and mixed SFN versus 98 patients without SFN. We distinguished between markers of dorsal root ganglia (DRG) degeneration (decreased IENFD in the proximal thigh versus the distal leg) versus axonal degeneration (decreased IENFD in the distal leg versus the proximal thigh). ## Results There were no differences in pain intensity, pain quality, and treatment characteristics in the comparison of 13 patients with pure SFN versus 10 patients with mixed SFN. Ten patients with SFN (approximately 45%) had neuropathic pain preceding sicca symptoms. Opioid analgesics were prescribed to approximately 45% of patients with SFN. When compared to 98 patients without SFN, the 23 patients with SFN had an increased frequency of male sex (30% versus 9%; __P__ < 0.01), a decreased frequency of anti–Ro 52 (__P__ = 0.01) and anti–Ro 60

Who reads Biopsy‐Proven Small‐Fiber Neuropathy in Primary Sjögren's Syndrome: Neuropathic Pain Characteristics, Autoantibody Findings, and Histopathologic Features?

Author

Julius Birnbaum; Aliya Lalji; Aveen Saed; Alan N. Baer

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 2151-464X)

Published

2018

Language

EN

Field

Medicine (Health Sciences)