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Can I read Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine on EtoBox?
Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine by Hans-Peter ECK; Wulf DRÖGE is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine about?
Cell culture experiments with approximately physiological amino-acid concentrations show that a 3-to 5-fold elevation of the extracellular glutamate concentration causes a substantial decrease of the intracellular cysteine and glutathione content of murine peritoneal macrophages. Our experiments show, moreover, that murine peritoneal macrophages, human peripheral blood monocytes, and murine fibroblastoid cells (L-cells) consume cystine and release cysteine into the extracellular space. This process was found to be markedly suppressed in all three cell types by a 3-to 5-fold increase of the extracellular glutamate concentration. Possible implications of these effects for the pathogenetic mechanism of the acquired immunodeficiency syndrome (AIDS) are discussed. ## Einfluß der extrazellulären Glutamat-Konzentration auf die intrazelluläre Cyst(e)in-Konzentration in Makrophagen und auf ihre Fähigkeit, Cystein freizusetzen Zusammenfassung: Zellkultur-Experimente mit Peritoneal-Makrophagen von Mäusen in einem Medium mit annähernd physiologischen Aminosäure-Konzentrationen haben gezeigt, daß eine ca. 3-Sfache Erhöhung der extrazellulären Glutamat-Konzentration eine substantielle Erniedrigu
Who reads Influence of the Extracellular Glutamate Concentration on the Intracellular Cyst(e)ine Concentration in Macrophages and on the Capacity to Release Cysteine?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hans-Peter ECK; Wulf DRÖGE
- Published
- 1989
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)