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Insulin Resistance: Causes and Consequences by Zachary T. Bloomgarden is a book available to read on EtoBox.

What is Insulin Resistance: Causes and Consequences about?

This review addresses aspects of the set of abnormalities of insulin action commonly referred to as ''insulin resistance.'' The condition is created by a state of differential insulin resistance, with the metabolic effects of insulin being diminished, while the mitogenic effects of insulin on cellular growth and differentiation are relatively overexpressed. Adiposity is a major aspect of insulin resistance, with adipocyte secretory products playing an important role in decreasing insulin response. These include interleukin (IL) 6, tumor necrosis factor (TNF)-, resistin, and interferon (IF)-. Adiponectin is an adipokine which acts to increase insulin sensitivity, with levels decreased in persons with insulin resistance. An additional potential mechanism is the association of obesity with the accumulation of macrophages in adipose tissue. The importance of the adipocyte is underscored by the effect of thiazolidinediones (TZD), an important group of oral hypoglycemic agents whose principal effect appears to be in increasing adipocyte differentiation and in increasing adipocyte insulin action. Interestingly, expression of macrophage-originated genes is downregulated following treatment

Author

Zachary T. Bloomgarden

Publisher

Elsevier

Published

2005

Language

EN