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Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-B1 by Kazunori Kitagawa; Atsuo Murata; Nariaki Matsuura; Kazuo Tohya; Shigeko Takaichi; Morito Monden; Masaki Inoue is a Medicine article available to read on EtoBox.

What is Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-B1 about?

We report on 2 cell lines (designated OVAK-I and OVAK-II) established from an adenosarcoma, a rare variant of a malignant Mullerian mixed tumor, of the ovary. OVAK-I was not tumorigenic in nude mice and showed no responsiveness to transforming growth factor (TGF)-f! I, whereas OVAK-II was tumorigenic and had various biological properties. Light-and electronmicroscopic studies showed that the morphology of the cells was converted from an epithelial to a mesenchymal form by TGF-f! I. Furthermore, the protein and mRNA expressions of the epithelial marker carcinoembryonic antigen and the mesenchymal marker virnentin were down-and up-regulated, respectively, by TGF-f! I. These findings suggested that TGF-fl I plays a role in epithelial-mesenchymal transformation and support the single-stem-cell theory which explains the origin of malignant Mullerian mixed tumors: that the epithelial and mesenchymal components of these tumors are of common stem-cell origin.

Who reads Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-B1?

Author

Kazunori Kitagawa; Atsuo Murata; Nariaki Matsuura; Kazuo Tohya; Shigeko Takaichi; Morito Monden; Masaki Inoue

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1996

Language

EN

Field

Medicine (Health Sciences)