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Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review by Arnts, Janique; Vanlerberghe, Benedict TK; Roozen, Sylvia; Crunelle, Cleo L; Masclee, Ad AM; OldeâDamink, Steven WM; Heeren, Ron MA; van Nuijs, Alexander; Neels, Hugo; Nevens, Frederik; Verbeek, Jef is a Medicine article available to read on EtoBox.
What is Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review about?
## Background and aims: Alcohol-related liver disease is the most frequent cause of cirrhosis and a major indication for liver transplantation. several alcohol use biomarkers have been developed in recent years and are already in use in several centers. however, in patients with liver disease their diagnostic performance might be influenced by altered biomarker formation by hepatic damage, altered excretion by kidney dysfunction and diuretics use, and altered deposition in hair and nails. we systematically reviewed studies on the diagnostic accuracy of biomarkers of alcohol use in patients with liver disease and performed a detailed study quality assessment. ## Methods: A structured search in pubmed/medline/embase databases was performed for relevant studies, published until april 28, 2019. the risk of bias and applicability concerns was assessed according to the adapted quality assessment of diagnostic accuracy studies-2 (quadas-2) checklist. ## Results: Twelve out of 6,449 studies met inclusion criteria. urinary ethyl glucuronide and urinary ethyl sulfate showed high sensitivity (70 to 89 and 73 to 82%, respectively) and specificity (93 to 99 and 86 to 89%, respectively) for asse
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- Author
- Arnts, Janique; Vanlerberghe, Benedict TK; Roozen, Sylvia; Crunelle, Cleo L; Masclee, Ad AM; OldeâDamink, Steven WM; Heeren, Ron MA; van Nuijs, Alexander; Neels, Hugo; Nevens, Frederik; Verbeek, Jef
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 0145-6008)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)