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Can I read A Novel Lymphatic Pattern Promotes Metastasis of Cervical Cancer in a Hypoxic Tumour-associated Macrophage-dependent Manner on EtoBox?
A Novel Lymphatic Pattern Promotes Metastasis of Cervical Cancer in a Hypoxic Tumour-associated Macrophage-dependent Manner by Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Novel Lymphatic Pattern Promotes Metastasis of Cervical Cancer in a Hypoxic Tumour-associated Macrophage-dependent Manner about?
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying mechanisms remain unclear. Here, we uncovered a novel lymphatic pattern in the hypoxic TME, wherein lymphatic vessels (LVs) are encapsulated by tumour-associated macrophages (TAMs) to form an interconnected network. We describe these aggregates as LVEM (LVs encapsulated by TAMs) considering their advantageous metastatic capacity and active involvement in early lymph node metastasis (LNM). Mechanistic investigations revealed that interleukin-10 (IL-10) derived from hypoxic TAMs adjacent to LVs was a prerequisite for lymphangiogenesis and LVEM formation through its induction of Sp1 upregulation in lymphatic endothelial cells (LECs). Interestingly, Sp1^high^ LECs promoted the transactivation of C–C motif chemokine ligand 1 (CCL1) to facilitate TAM and tumour cell recruitment, thereby forming a positive feedback loop to strengthen the LVEM formation. Knockdown of Sp1 or blockage of CCL1 abrogated LVEM and consequently attenuated LNM. Notably, CSCC^non-LNM^ is largely devoid of hypoxic TAMs and the resultant LVEM,
Who reads A Novel Lymphatic Pattern Promotes Metastasis of Cervical Cancer in a Hypoxic Tumour-associated Macrophage-dependent Manner?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)