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Ascorbic Acid Protects Against Levodopa-induced Neurotoxicity on a Catecholamine-rich Human Neuroblastoma Cell Line by Beatriz Pardo; María Angeles Mena; Stanley Fahn; Justo García de Yébenes is a Medicine article available to read on EtoBox.

What is Ascorbic Acid Protects Against Levodopa-induced Neurotoxicity on a Catecholamine-rich Human Neuroblastoma Cell Line about?

## Abstract Levodopa, at concentrations of 0.25 × 10^−4^ __M__ or larger, is toxic for the human neuroblastoma cell NB69. Toxicity is associated with high levels of quinones, increased activity of complex II‐III, and lack of changes of complex I of the mitochondrial respiratory chain. Deprenyl, which does not alter the production of quinones, has a partial protective effect. Tocopherol, 23 or 115 × 10^−6^ __M__, lacks significant preventive effect on levodopa toxicity, but ascorbic acid, 10^−3^ __M__, prevents levodopa toxicity and quinone formation. Deprenyl, 10^−4^ __M__, provides additional protection in cultures treated with levodopa and ascorbic acid. Our results indicate that ascorbic acid and deprenyl prevent levodopa neurotoxicity by unrelated mechanisms. Both compounds should be considered as complementary drugs to test for slowing the progression of Parkinson's disease.

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Author

Beatriz Pardo; María Angeles Mena; Stanley Fahn; Justo García de Yébenes

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1993

Language

EN

Field

Medicine (Health Sciences)