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End binding protein‐1 (EB1) complements microtubule‐associated protein‐1B during axonogenesis by Eva M. Jiménez‐Mateos; Gabriela Paglini; Christian González‐Billault; Alfredo Cáceres; Jesús Avila is a Neuroscience article available to read on EtoBox.
What is End binding protein‐1 (EB1) complements microtubule‐associated protein‐1B during axonogenesis about?
## Abstract The different strains of microtubule‐associated protein (MAP)‐1B‐deficient mice that have been generated appear to express different phenotypes. This variability could be the consequence of the distinct genetic backgrounds of the animals used to generate these lines. Certain proteins might be able to complement the deficit of MAP1B function in these mice. Therefore, we examined whether the concentrations of potential compensatory proteins varied among these mutant strains. In this way, we identified significant differences in the amounts of the microtubule‐associated EB1 protein between two of these strains. Furthermore, in transfection studies, we demonstrated that the overexpression of end binding protein‐1 (EB1) could facilitate axonogenesis in MAP1B–/– cells in which EB1 is normally weakly expressed. Thus, we suggest that EB1 could complement MAP1B function during neural development. © 2005 Wiley‐Liss, Inc.
Who reads End binding protein‐1 (EB1) complements microtubule‐associated protein‐1B during axonogenesis?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Eva M. Jiménez‐Mateos; Gabriela Paglini; Christian González‐Billault; Alfredo Cáceres; Jesús Avila
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)