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The study investigates the effects of cigarette smoke extract on esophageal epithelial cells, revealing that chronic exposure leads to cellular transformation characterized by increased glycolysis and mitochondrial dysfunction. Resistant cells showed enhanced growth and invasion capabilities, alongside altered expression of epithelial and mesenchymal markers. These findings suggest that cigarette smoke significantly contributes to the development of a tumorigenic phenotype in nonmalignant esophageal cells.
- Author
- susan.zuniga.dvillar
- Language
- EN