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New pentacoordinated Schiff-base diorganotin(IV) complexes derived from nonpolar side chain α-amino acids by Nikoloz Kobakhidze; Norberto Farfán; Margarita Romero; J. Manuel Méndez-Stivalet; M. Gabriela Ballinas-López; Héctor García-Ortega; Oscar Domínguez; Rosa Santillan; Francisco Sánchez-Bartéz; Isabel Gracia-Mora is a Chemistry article available to read on EtoBox.

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In this work we report the synthesis and spectroscopic characterization of twenty new pentacoordinated diorganotin(IV) compounds. These compounds have been prepared in good yields by multicomponent reactions (MCRs) of a-amino acids (isoleucine, leucine, methionine, phenylalanine and aminophenylacetic acid), 2,4-dihydroxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde and either di-n-butyltin(IV) oxide or diphenyltin(IV) oxide. All compounds were characterized by IR spectroscopy, 1 H, 119 Sn and 13 C NMR spectroscopy and mass spectrometry. Each compound has a coordinative N?Sn bond and shows the expected 119 Sn NMR chemical shift indicative of a pentacoordinated or hexacoordinated tin atom in CDCl 3 and DMSO-d 6 , respectively. These compounds were also tested in tumoral cell lines, HeLa, HCT-15 and MCF-7, in order to evaluate the antiproliferative activity and to obtain the medial inhibitory concentrations (IC 50 ) values.

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Author

Nikoloz Kobakhidze; Norberto Farfán; Margarita Romero; J. Manuel Méndez-Stivalet; M. Gabriela Ballinas-López; Héctor García-Ortega; Oscar Domínguez; Rosa Santillan; Francisco Sánchez-Bartéz; Isabel Gracia-Mora

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0022-328X)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)