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Polyphenols in red wine inhibit the proliferation and induce apoptosis of LNCaP cells by I. Romero; A. Páez; A. Ferruelo; M. Luján; A. Berenguer is a Medicine article available to read on EtoBox.

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**Objective** To assess the effect of five polyphenol constituents of red wine (quercetin, morin, rutin, gallic acid and tannic acid) on the proliferation of LNCaP cells, and to quantify the extent of apoptosis with each polyphenol. **Materials and methods** LNCaP cells (500) were cultured in microtitre plates and treated with gallic acid, tannic acid, quercetin (1, 5 and 10 μmol/L), rutin and morin (25, 50 and 75 μmol/L). A colorimetric immunoassay was then used to determine the extent of proliferation at 24, 48, 72 and 96 h, and a cell‐death detection assay to assess apoptosis at 24, 48 and 72 h. **Results** Gallic and tannic acid (5 and 10 μmol/L), morin (50 and 75 μmol/L), quercetin (5 and 10 μmol/L) and rutin (50 and 75 μmol/L) all significantly inhibited (__P__<0.05) cell proliferation compared with the control. Apoptotic indexes were significantly greater (__P__<0.01) in the presence of gallic (5 and 10 μmol/L) and tannic acid (5 and 10 μmol/L), and rutin (75 μmol/L, __P__<0.05) than in the control. The apoptotic effect of morin (75 μmol/L), although significant (__P__<0.01), only appeared at 72 h. Conversely, while significant (__P__<0.05) quercetin (5 and 10 μmol/L) had a

Who reads Polyphenols in red wine inhibit the proliferation and induce apoptosis of LNCaP cells?

Author

I. Romero; A. Páez; A. Ferruelo; M. Luján; A. Berenguer

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

2002

Language

EN

Field

Medicine (Health Sciences)