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Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study by Akira Fukao; Shouko Komatsu; Yoshitaka Tsubono; Shigeru Hisamichi; Hitoshi Ohori; Takeshi Kizawa; Noriko Ohsato; Norio Fujino; Nobuyoshi Endo; Masaharu Iha is a Medicine article available to read on EtoBox.
What is Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study about?
To evaluate an association between Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis (CAG), an established precursor of gastric cancer, we performed a cross-sectional study using IgG antibody against H. pylori and pepsinogens of blood donors in four prefectures in Japan. Although a geographic correlation between the age-adjusted prevalence rates for H. pylori infection and those for CAG was not seen, the age-adjusted odds ratios (OR) of H. pylori infection for CAG were high in each area (around five for men and from four to 12.6 for women). The association between them weakened with advancing age; the ORs in the youngest age group (16-29 yrs) and in the oldest age group (50-64 yrs) were 12.5 and 2.8 for men, and 11.5 and 5.2 for women, respectively. These findings suggest that H. pylori infection is strongly associated with CAG, while there are some other factors interacting in the development of CAG. A prospective cohort study in which CAG and H. pylori infection are taken into account will be necessary to assess the risks of gastric cancer.
Who reads Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study?
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- Author
- Akira Fukao; Shouko Komatsu; Yoshitaka Tsubono; Shigeru Hisamichi; Hitoshi Ohori; Takeshi Kizawa; Noriko Ohsato; Norio Fujino; Nobuyoshi Endo; Masaharu Iha
- Publisher
- Springer Netherlands; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0957-5243)
- Published
- 1993
- Language
- EN
- Field
- Medicine (Health Sciences)