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Differential Redox Potential Profiles During Adipogenesis and Osteogenesis by Barry R. Imhoff; Jason M. Hansen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Differential Redox Potential Profiles During Adipogenesis and Osteogenesis about?

## Abstract Development is an orderly process that requires the timely activation and/or deactivation of specific regulatory elements that control cellular proliferation, differentiation and apoptosis. While many studies have defined factors that control developmental signaling, the role of intracellular reduction/oxidation (redox) status as a means to control differentiation has not been fully studied. Redox states of intracellular couples may play a very important role in regulating redox-sensitive elements that are involved in differentiation signaling into specific phenotypes. In human mesenchymal stem cells (hMSCs), which are capable of differentiating into many different types of phenotypes, including osteoblasts and adipocytes, glutathione (GSH), cysteine (Cys) and thioredoxin-1 (Trx1) redox potentials were measured during adipogenesis and osteogenesis. GSH redox potentials (Eh) during both osteogenesis and adipogenesis became increasingly oxidized as differentiation ensued, but the rate at which this oxidation occurred was unique for each process. During adipogenesis, Cys Eh became oxidized as adipogenesis progressed but during osteogenesis, it became reduced. Interestingly

Who reads Differential Redox Potential Profiles During Adipogenesis and Osteogenesis?

Author

Barry R. Imhoff; Jason M. Hansen

Publisher

SP Versita; Springer (Biomed Central Ltd.); BioMed Central Ltd.; Springer Science and Business Media LLC; Walter de Gruyter GmbH (ISSN 1425-8153)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)