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Doublecortin by raygarcia95 is a document available to read on EtoBox.
The article investigates the role of Doublecortin (DCX), a microtubule-associated protein, in regulating neuronal branching and tubulin polyglutamylation. Using CRISPR/Cas9 to create DCX knockout neurons, the study finds that loss of DCX leads to impaired nuclear movement and increased neurite branching, which can be rescued by reintroducing DCX or the enzyme TTLL11. The findings suggest that DCX is a critical regulator of the neuronal microtubule structure and function, impacting neuronal migration and dev
- Author
- raygarcia95
- Language
- EN