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GLP-1R in IBD: Nerve Innervation Insights by Andi Susilo is a document available to read on EtoBox.

What is GLP-1R in IBD: Nerve Innervation Insights about?

This study found increased levels of the glucagon-like peptide 1 receptor (GLP-1R) and sensory/nociceptor innervation in inflammatory bowel disease (IBD) gut tissues. GLP-1R was also present in human dorsal root ganglion (DRG) neurons. Immunohistochemistry analysis showed significantly higher numbers of GLP-1R and CGRP fibers in IBD colon biopsy samples compared to controls. In cultured DRG neurons, incretin hormones like GLP-1 promoted neurite outgrowth. While ATP signaling was enhanced, capsaicin sensitiv

Author

Andi Susilo

Language

EN